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Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome

Author

Listed:
  • JH An

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • KB Kim

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • SC Kwon

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • HJ Kim

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • MO Ryu

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • YI Oh

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

  • JO Ahn

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Republic of Korea Ju-Hyun An and Kyeong-Bo Kim contributed equally to this work)

  • HY Youn

    (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea)

Abstract

Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2-4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

Suggested Citation

  • JH An & KB Kim & SC Kwon & HJ Kim & MO Ryu & YI Oh & JO Ahn & HY Youn, 2022. "Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(4), pages 206-211.
    • Handle: RePEc:caa:jnlvet:v:67:y:2022:i:4:id:213-2020-vetmed
    DOI: 10.17221/213/2020-VETMED
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