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Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agent

Author

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  • J Kim

    (Department of Veterinary Internal Medicine, Chonnam National University, Yongbong-ro, Buk-gu, Gwangju, Republic of Korea)

  • HJ Kim

    (Department of Veterinary Internal Medicine, Chonnam National University, Yongbong-ro, Buk-gu, Gwangju, Republic of Korea)

Abstract

A two-year-old spayed female American shorthair cat presented with a rough, circular, exophytic mass on the genital area. The clinical findings and histopathological examination revealed that the mass contained neoplastic mast cells and, thus, was diagnosed as a mast cell tumour. The anatomical location of the mass was not easily accessible for surgical intervention. We administered a targeted therapy using oral imatinib mesylate for eight weeks to reduce the size of the lesion and to facilitate the successful surgical removal. The tumour mass eventually reduced by 21% and was surgically excised. This is possibly the first study to use imatinib mesylate as a tumour reduction neoadjuvant to therapeutically address a feline cutaneous mast cell tumour located in a surgically inaccessible part of the body.

Suggested Citation

  • J Kim & HJ Kim, 2020. "Treatment of a feline cutaneous mast cell tumour using imatinib mesylate as a neoadjuvant tyrosine kinase inhibitor therapeutic agent," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 65(2), pages 84-88.
    • Handle: RePEc:caa:jnlvet:v:65:y:2020:i:2:id:91-2019-vetmed
    DOI: 10.17221/91/2019-VETMED
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