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Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report

Author

Listed:
  • Joong Hyun Song

    (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea)

  • Tae Sung Hwang

    (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea)

  • Hee Chun Lee

    (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea)

  • Do Hyeon Yu

    (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea)

  • Byung Joon Seung

    (College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea)

  • Jung Hyang Sur

    (College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea)

  • Dong In Jung

    (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea)

Abstract

A seven-year-old Toy Poodle was presented for progressive ataxia and seizure episodes. Magnetic resonance imaging revealed inflammatory lesions in the cerebrum and brainstem. Management with imatinib mesylate, prednisolone and hydroxyurea were initiated and resulted in complete resolution of the clinical signs. In regular magnetic resonance imaging scans, the overall appearance of the lesions deteriorated but improved again after an increase in the imatinib mesylate dose. The patient had not shown any neurological signs until death and survived for 1052 days after initial presentation. On histopathological examination, the patient was diagnosed with disseminated granulomatous meningoencephalitis involving the cerebrum and brainstem. Immunohistochemical staining was performed on the five types of tyrosine kinase (PDGFR-α, PDGFR-ß, VEGFR-2, c-Kit and c-Abl proteins), which constitute therapeutic targets for conventional multitargeted tyrosine kinase inhibitors. The immunohistochemical analysis revealed that all these tyrosine kinases were expressed in the brain samples. The present report describes the first case of the use of imatinib mesylate therapy for granulomatous meningoencephalitis in the dog. Therapy with imatinib mesylate plus glucocorticoids appears promising as a new therapeutic intervention in meningoencephalitis of unknown aetiology.

Suggested Citation

  • Joong Hyun Song & Tae Sung Hwang & Hee Chun Lee & Do Hyeon Yu & Byung Joon Seung & Jung Hyang Sur & Dong In Jung, 2019. "Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 64(2), pages 92-99.
    • Handle: RePEc:caa:jnlvet:v:64:y:2019:i:2:id:70-2018-vetmed
    DOI: 10.17221/70/2018-VETMED
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