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Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells

Author

Listed:
  • Minho Ko

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Tae Hyeong Kim

    (Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Yoonhwan Kim

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Doo Kim

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Jin-Ok Ahn

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Byung-Jae Kang

    (Department of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Sooyoung Choi

    (Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Gangwondo, Republic of Korea)

  • Inchul Park

    (Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Gangwondo, Republic of Korea)

  • Jung Hoon Choi

    (Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

  • Jin Young Chung

    (Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea)

Abstract

A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient's walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

Suggested Citation

  • Minho Ko & Tae Hyeong Kim & Yoonhwan Kim & Doo Kim & Jin-Ok Ahn & Byung-Jae Kang & Sooyoung Choi & Inchul Park & Jung Hoon Choi & Jin Young Chung, 2019. "Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 64(10), pages 462-466.
    • Handle: RePEc:caa:jnlvet:v:64:y:2019:i:10:id:46-2019-vetmed
    DOI: 10.17221/46/2019-VETMED
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    Keywords

    dog; SLE; stem cell therapy;
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