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Angiokeratoma with lysosomal dilatation in keratinocytes in a dog: a case report

Author

Listed:
  • H.K. Lim

    (College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea)

  • H.J. Kim

    (College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea)

  • H.R. Lee

    (College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea)

  • S. Han

    (Hansu Animal Clinic, Seoul, Republic of Korea)

  • S.H. Do

    (College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea)

Abstract

Herein, we report the histopathology of angiokeratoma characterised by non-invasive, proliferative, ectatic vascular malformations accompanying lysosomal dilation in the canine skin. Two cutaneous angiokeratomas were diagnosed in a six-year-old spayed female Pekinese dog. Physical examination of the skin revealed two small erythematous papules on the axillary and abdominal regions. The masses were approximately 2-3 mm in diameter, well-circumscribed, purple to red in colour, and slightly elevated above the skin surface. The two small masses had similar histopathological features, characterised by exophytic proliferation of a mixture of multiple vascular channels resembling a cavernous haemangioma on the superficial dermis. The entire lesion was well circumscribed and the overlying epidermal hyperplasia formed a collarette. Ultrastructural analysis with transmission electron microscopy revealed electron-lucent lysosomal dilatation in the keratinocytes of the irregular hyperplastic epithelial trabeculae like rete pegs.

Suggested Citation

  • H.K. Lim & H.J. Kim & H.R. Lee & S. Han & S.H. Do, 2014. "Angiokeratoma with lysosomal dilatation in keratinocytes in a dog: a case report," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 59(9), pages 453-456.
    • Handle: RePEc:caa:jnlvet:v:59:y:2014:i:9:id:7686-vetmed
    DOI: 10.17221/7686-VETMED
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