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Pharmacokinetics and pharmacodynamics of a novel amoxicillin/sulbactam/prednisolone intramammary infusion in lactating cows after repeated administrations

Author

Listed:
  • H. Li

    (College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China)

  • G.Q. Wu

    (Bayer (Sichuan) Animal Health Co., Beijing, P.R. China)

  • S.S. Tang

    (College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China)

  • X.L. Xiao

    (College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China)

  • J.C. Li

    (College of Veterinary Medicine, China Agricultural University, Beijing, P.R. China)

Abstract

The aim of this study was to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of a novel anti-mastitis preparation, amoxicillin/sulbactam/prednisolone intramammary infusion (CAIMM), containing 200 mg amoxicillin, 50 mg sulbactam and 10 mg prednisolone per 3 g formulation, in healthy lactating cows after repeated administrations. A parallel study was performed using the available combination product (Synulox® LC) from Pfizer, with the aim of comparing the two formulations. The concentrations of drugs in quarter milk were determined using the ultra-high performance liquid chromatography tandem mass spectrometric (UPLC-MS/MS) method. No significant difference in the major PK parameters (Cmax, Tmax, MRT, t1/2λ, and AUClast) was observed. The MIC90 determined in 106 isolated Staphylococcus spp., 64 Streptococcus spp. and 18 Escherichia coli strains was 0.5, 0.25 and 2 μg/ml, respectively. The PK/PD evaluation showed that the effective duration of action (t > MIC90) for CAIMM (42 ± 2.46 h) was increased by 0.86 times compared with Synulox® LC (34 ± 3.17 h), but the difference was not significant (P > 0.05). This pharmacokinetic and pharmacodynamic study revealed that CAIMM maintained high concentrations in quarter milk for the three ingredients after repeated intramammary administrations and a similar efficacy was achieved with Synulox® LC.

Suggested Citation

  • H. Li & G.Q. Wu & S.S. Tang & X.L. Xiao & J.C. Li, 2014. "Pharmacokinetics and pharmacodynamics of a novel amoxicillin/sulbactam/prednisolone intramammary infusion in lactating cows after repeated administrations," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 59(5), pages 221-229.
    • Handle: RePEc:caa:jnlvet:v:59:y:2014:i:5:id:7515-vetmed
    DOI: 10.17221/7515-VETMED
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    References listed on IDEAS

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    1. U.K. De & R. Mukherjee, 2012. "Dynamics of milk leukocytes in response to intramammary infusion of amoxicillin plus sulbactam during bovine subclinical mastitis," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(11), pages 583-590.
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