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Lactoferrin: a review

Author

Listed:
  • L. Adlerova

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • A. Bartoskova

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic)

  • M. Faldyna

    (University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
    Veterinary Research Institute, Brno, Czech Republic)

Abstract

This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and differentiation, and antibacterial, antiviral, and antiparasitic activity. Many of these functions do not appear to be connected with its iron binding ability. Of late, lactoferrin concentrations have been measured mostly in humans but also in some other species. However, the relationship between its concentration and physiological or pathological effects on body functions is not yet well characterised.

Suggested Citation

  • L. Adlerova & A. Bartoskova & M. Faldyna, 2008. "Lactoferrin: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(9), pages 457-468.
    • Handle: RePEc:caa:jnlvet:v:53:y:2008:i:9:id:1978-vetmed
    DOI: 10.17221/1978-VETMED
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    Cited by:

    1. C. Tothova & O. Nagy & G. Kovac, 2014. "Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 59(4), pages 163-180.

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