IDEAS home Printed from https://ideas.repec.org/a/caa/jnlvet/v53y2008i2id1986-vetmed.html
   My bibliography  Save this article

Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats

Author

Listed:
  • J. Matiasovic

    (Veterinary Research Institute, Brno, Czech Republic)

  • L. Leva

    (Veterinary Research Institute, Brno, Czech Republic)

  • J. Maskova

    (Veterinary Research Institute, Brno, Czech Republic)

  • V. Kummer

    (Veterinary Research Institute, Brno, Czech Republic)

  • M. Faldyna

    (Veterinary Research Institute, Brno, Czech Republic)

Abstract

To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-γ and IL-4 (measured at the mRNA level) as well as the decreasing IFN-γ /IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination.

Suggested Citation

  • J. Matiasovic & L. Leva & J. Maskova & V. Kummer & M. Faldyna, 2008. "Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(2), pages 93-100.
    • Handle: RePEc:caa:jnlvet:v:53:y:2008:i:2:id:1986-vetmed
    DOI: 10.17221/1986-VETMED
    as

    Download full text from publisher

    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/1986-VETMED.html
    Download Restriction: free of charge
    File URL: http://vetmed.agriculturejournals.cz/doi/10.17221/1986-VETMED.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/1986-VETMED?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlvet:v:53:y:2008:i:2:id:1986-vetmed. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.