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Quinolones: a class of antimicrobial agents

Author

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  • G. Sárközy

    (Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, Budapest, Hungary)

Abstract

The fluoroquinolones are a series of synthetic antibacterial agents that are used in the treatment of a variety of bacterial infections. These agents inhibit the DNA gyrase, abolishing its activity by interfering with the DNA-rejoining reaction. The inhibition of the resealing leads to the liberation of fragments that are subsequently destroyed by the bacterial exonucleases. All fluoroquinolones accumulate within bacteria very rapidly, so that a steady-state intrabacterial concentration is obtained within a few minutes. Resistance develops slowly and is usually chromosomal and not plasmid mediated. However, development of resistance and transfer between animal and human pathogens has become a fervently argued issue among the microbiologists. Another concern regarding the use of new quinolones in the veterinary field is a possible detrimental effect on the environment. It still seems unlikely that the controlled use of veterinary quinolones will give rise to unfavorable effects on the environment.

Suggested Citation

  • G. Sárközy, 2001. "Quinolones: a class of antimicrobial agents," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 46(9-10), pages 257-274.
    • Handle: RePEc:caa:jnlvet:v:46:y:2001:i:9-10:id:7883-vetmed
    DOI: 10.17221/7883-VETMED
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