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Effect of vitamin E and selenium on blood glutathione peroxidase activity and some immunological parameters in sheep

Author

Listed:
  • K. Milad

    (University of Veterinary Medicine, Košice, Slovak Republic)

  • G. Kováč

    (University of Veterinary Medicine, Košice, Slovak Republic)

  • O. Rácz

    (University of Veterinary Medicine, Košice, Slovak Republic)

  • A. Šipulová

    (University of Veterinary Medicine, Košice, Slovak Republic)

  • V. Bajová

    (University of Veterinary Medicine, Košice, Slovak Republic)

Abstract

The objective of this study was to determine the effect of vitamin E and selenium administration on glutathione peroxidase (GSH-Px) activity and selected parameters of cellular immunity (metabolic activity, phagocytic activity, lymphocyte blastogenic response). Nine pregnant sheep with body weight of 42 to 66 kg were divided into two groups. Before lambing, the first group (n = 5) was given subcutaneously 5 mg vitamin E and 0.4 mg selenium per kg body weight while the second group (n = 4) was given no treatment and served as control. Blood samples from all sheep were collected before the treatment, 14 days after lambing and 30 days after lambing. Whole blood GSH-Px activities were significantly higher in the vitamin E and selenium treated sheep than in the control in the samples taken 14 days after lambing and 30 days after lambing (P < 0.01; P < 0.001, respectively). The evaluation of immunological parameters showed declines in immunological parameters measured on days 14 and 30 after lambing. The administered preparation led to significant effects (P < 0.001; P < 0.05) on phagocytic activity index of leukocytes and phagocytic activity index of neutrophils, respectively.

Suggested Citation

  • K. Milad & G. Kováč & O. Rácz & A. Šipulová & V. Bajová, 2001. "Effect of vitamin E and selenium on blood glutathione peroxidase activity and some immunological parameters in sheep," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 46(1), pages 1-5.
    • Handle: RePEc:caa:jnlvet:v:46:y:2001:i:1:id:7843-vetmed
    DOI: 10.17221/7843-VETMED
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    Cited by:

    1. J. Trávníček & J. Racek & L. Trefil & H. Rodinová & V. Kroupová & J. Illek & J. Doucha & L. Písek, 2008. "Activity of glutathione peroxidase (GSH-Px) in the blood of ewes and their lambs receiving the selenium-enriched unicellular alga Chlorella," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 53(7), pages 292-298.

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