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Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activity

Author

Listed:
  • Subhashini Ramakrishnan

    (Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India)

  • Thomas Jebastin

    (Computer Aided Drug Designing Lab, Department of Bioinformatics, Bishop Heber College (Autonomous), Tamil Nadu, India)

  • Sumathy Raj

    (Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India)

  • Ariyamuthu Ramathilaga

    (Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India)

  • Rithik Selvaraj

    (Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India)

  • Najat A. Bukhari A.

    (Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia)

  • Ashraf Atef Hatamleh

    (Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia)

  • Anis Ahamed

    (Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia)

Abstract

Carbohydrate digestive enzymes like α-amylase and α-glucosidase can be used to treat and manage diabetes. By inhibiting these enzymes, carbohydrate digestion slowed down, lowering the level of glucose entry into the bloodstream and preventing postprandial hyperglycemia. However, the effectiveness of current antidiabetic agents is limited due to their adverse effects. Therefore, the current study explored natural inhibitors from the methanol extract of rice to combat this issue. Through an integrated approach, four different rice cultivars were analysed and found that red rice methanol extract compounds stigmasterol and 1,2-benzenedicarboxylic acid interacted with α-amylase and α-glucosidase. Additionally, further research on stigmasterol directs the structure-activity relationship studies that aid in managing diabetic conditions.

Suggested Citation

  • Subhashini Ramakrishnan & Thomas Jebastin & Sumathy Raj & Ariyamuthu Ramathilaga & Rithik Selvaraj & Najat A. Bukhari A. & Ashraf Atef Hatamleh & Anis Ahamed, 2024. "Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activity," Plant, Soil and Environment, Czech Academy of Agricultural Sciences, vol. 70(11), pages 683-694.
    • Handle: RePEc:caa:jnlpse:v:70:y:2024:i:11:id:150-2024-pse
    DOI: 10.17221/150/2024-PSE
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