IDEAS home Printed from https://ideas.repec.org/a/caa/jnlcjf/v35y2017i4id584-2015-cjfs.html
   My bibliography  Save this article

Curcumin and its allied analogues: epigenetic and health perspectives - a review

Author

Listed:
  • Muhammad Imran

    (Department of Diet and Nutritional Sciences, Imperial College of Business Studies, Lahore, Pakistan)

  • Muhammad Nadeem

    (Department of Environmental Sciences, CoMsaTs Institute of Information Technology, Vehari, Pakistan)

  • Muhammad Asif Khan

    (University of Agriculture, Faisalabad-sub Campus Burewala/Vehari, Pakistan)

  • Sheraz Ahmed

    (Department of Food Science and Technology, Islamia University of Bhawalpur, Bhawalpur, Pakistan)

  • Ali Imran

    (Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan)

  • Rai Muhammad Amir

    (Institute of Food and Nutritional Sciences, Pmas-Arid Agriculture University, Rawalpindi, Pakistan)

  • Muhammad Umair Arshad

    (Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan)

  • Syed Amir Gilani

    (Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan)

  • Farhan Saeed

    (Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan)

  • Abdur Rauf

    (Department of Chemistry, University of Swabi, Ankbar Swabi, Pakistan)

  • Zaffar Mehmood

    (Department of Biological Sciences, Forman Christian College, Lahore, Pakistan)

  • Shaista Khan
  • Hafiz Ansar Rasul Suleria

Abstract

Curcumin (diferuoyl methane) is a yellow active ingredient present in turmeric. It is a homodimer of feruloylmethane that comprises a hydroxyl and methoxy group (heptadiene with two Michael acceptors), and α-, β-diketone. It contains various metabolites, i.e. hexahydrocurcumin (HHC), tetrahydrocurcumin (THC), octahydrocurcumin (OHC), dihydrocurcumin (DHC), curcumin sulphate, and curcumin glucuronide. Curcumin has been proven the most effective histone deacetylase (HDAC) inhibitor in HeLa nuclear extracts. It has the ability to affect the Akt, growth factors, NF-kB, and metastatic and angiogenic pathways. Curcumin has a strong therapeutic or preventive potential against several major human ailments, i.e. suppression of inflammation, cardiovascular, diabetes, tumorigenesis, chronic fatigue, antidepressant and neurological activities, depression, loss of muscle and bone, and neuropathic pain. In future, higher utilisation of curcumin as an active agent in food based products is required to curtail the human health disorders.

Suggested Citation

  • Muhammad Imran & Muhammad Nadeem & Muhammad Asif Khan & Sheraz Ahmed & Ali Imran & Rai Muhammad Amir & Muhammad Umair Arshad & Syed Amir Gilani & Farhan Saeed & Abdur Rauf & Zaffar Mehmood & Shaista K, 2017. "Curcumin and its allied analogues: epigenetic and health perspectives - a review," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 35(4), pages 285-310.
    • Handle: RePEc:caa:jnlcjf:v:35:y:2017:i:4:id:584-2015-cjfs
    DOI: 10.17221/584/2015-CJFS
    as

    Download full text from publisher

    File URL: http://cjfs.agriculturejournals.cz/doi/10.17221/584/2015-CJFS.html
    Download Restriction: free of charge
    File URL: http://cjfs.agriculturejournals.cz/doi/10.17221/584/2015-CJFS.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/584/2015-CJFS?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Masanori Sano & Tohru Minamino & Haruhiro Toko & Hideyuki Miyauchi & Masayuki Orimo & Yingjie Qin & Hiroshi Akazawa & Kaoru Tateno & Yosuke Kayama & Mutsuo Harada & Ippei Shimizu & Takayuki Asahara & , 2007. "p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload," Nature, Nature, vol. 446(7134), pages 444-448, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fabian Peisker & Maurice Halder & James Nagai & Susanne Ziegler & Nadine Kaesler & Konrad Hoeft & Ronghui Li & Eric M. J. Bindels & Christoph Kuppe & Julia Moellmann & Michael Lehrke & Christian Stopp, 2022. "Mapping the cardiac vascular niche in heart failure," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Toshiyuki Ko & Seitaro Nomura & Shintaro Yamada & Kanna Fujita & Takanori Fujita & Masahiro Satoh & Chio Oka & Manami Katoh & Masamichi Ito & Mikako Katagiri & Tatsuro Sassa & Bo Zhang & Satoshi Hatsu, 2022. "Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlcjf:v:35:y:2017:i:4:id:584-2015-cjfs. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.