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Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC

Author

Listed:
  • G. Chunsriimyatav

    (Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
    Institute of Chemistry and Chemical Technology, Mongolian Academy Sciences, Ulaanbaatar, MON 51 Mongolia)

  • I. Hoza

    (Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic)

  • P. Valášek

    (Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic)

  • S. Skrovanková

    (Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic)

  • D. Banzragch

    (Institute of Chemistry and Chemical Technology, Mongolian Academy Sciences, Ulaanbaatar, MON 51 Mongolia)

  • N. Tsevegsuren

    (Department of Organic Chemistry, Faculty of Chemistry, National University of Mongolia, Ulaanbaatar, Mongolia, *E-mail: chunsrii82@yahoo.com$2)

Abstract

Aerial parts of Saussurea salicifolia (L.) DC were studied for their lignan and flavonoids in solvent chloroform and n-butanol of ethanolic extract. Isolation and identification of phenolic compounds of the chloroform and n-butanol fractions were performed with Dionex HPLC-DAD system with water-methanol gradients in 4 different wave lengths (235 nm, 254 nm, 280 nm and 340 nm), using online UV and LC-MS as described previously. 9-OH-pinoresinol which is a lignan with anticancer activity was dominated in the chloroform fraction, whereas mainly flavonoid glycosides like quercetin-3-O-galactoside, apigenin-7-O-rhamnoside with anti-inflammatory effect were detected in the n-butanol fraction. Additionally, 9-OH-pinoresinol was also found in the n-butanol fraction. Anticancer tests were conducted in leukemia mouse lymphoma cells L5178Y at a concentration of 10 μg/ml of test compound. Crude ethanol extract of S. salicifolia reduced the growth of leukemia mouse lymphoma cells L5178Y to 23.8%.

Suggested Citation

  • G. Chunsriimyatav & I. Hoza & P. Valášek & S. Skrovanková & D. Banzragch & N. Tsevegsuren, 2009. "Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 27(SpecialIs), pages 256-258.
    • Handle: RePEc:caa:jnlcjf:v:27:y:2009:i:specialissue1:id:1097-cjfs
    DOI: 10.17221/1097-CJFS
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