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Tissue distribution and elimination of florfenicol in topmouth culter (Culter alburnus) after oral administration

Author

Listed:
  • Weifen WANG

    (College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China)

  • Xianjun DAI

    (College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China)

  • Zhiqiang LI

    (Xiaoshan School of Science and Technology, Zhejiang Ocean University, Hangzhou, Zhejiang Province, China)

  • Qingli MENG

    (College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China)

Abstract

The serum concentration and muscle residue of florfenicol following oral administration were evaluated in topmouth culter (Culter alburnus) under field conditions. Fishes were cultured in tanks and fed a commercial medicated diet containing 2000 mg/kg florfenicol in a single dose. The sampling was conducted at different intervals (0, 0.5, 1, 1.5, 2, 3, 4, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144, 168 h) after the cessation of medication. Drug analysis was carried out by HPLC. The maximum concentration (Cmax) of 10.8 μg/g in serum and 4.2 μg/g in muscle were reached at the same time (tmax) of 8 hours. If the EU MRL value of 1.0 μg/g is quoted for the topmouth culter tissue, the extrapolation of the data indicated that it will be passed after a 40.6 h withdrawal period for florfenicol in topmouth culter muscle.

Suggested Citation

  • Weifen WANG & Xianjun DAI & Zhiqiang LI & Qingli MENG, 2009. "Tissue distribution and elimination of florfenicol in topmouth culter (Culter alburnus) after oral administration," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 27(3), pages 214-221.
    • Handle: RePEc:caa:jnlcjf:v:27:y:2009:i:3:id:183-2008-cjfs
    DOI: 10.17221/183/2008-CJFS
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