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Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men

Author

Listed:
  • V. Šimánek

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • N. Škottová

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • J. Bartek

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • J. Psotová

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • P. Kosina

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • L. Balejová

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

  • J. Ulrichová

    (1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ)

Abstract

In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 years. They received either 858 mg of ESM (531 mg silymarin complex calculated on pure silibinin), or placebo, daily for the period of 60 days. No side effects were found. A routine biochemical analysis of the serum was performed as a measure of lipid and liver metabolism. Positive trend towards decreased serum cholesterol level and HDL-cholesterol increase was observed in the ESM group as compared to the placebo group. The serum antioxidant capacity was significantly higher in the ESM group. The results suggest the use of ESM as a dietary supplement for hypercholesterolemia.

Suggested Citation

  • V. Šimánek & N. Škottová & J. Bartek & J. Psotová & P. Kosina & L. Balejová & J. Ulrichová, 2001. "Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 19(3), pages 106-110.
    • Handle: RePEc:caa:jnlcjf:v:19:y:2001:i:3:id:6585-cjfs
    DOI: 10.17221/6585-CJFS
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    Cited by:

    1. L. Křížová & J. Watzková & J. Třináctý & M. Richter & M. Buchta, 2011. "Rumen degradability and whole tract digestibility of flavonolignans from milk thistle (Silybum marianum) fruit expeller in dairy cows," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 56(6), pages 269-278.
    2. R. Vecera & A. Zacharova & J. Orolin & N. Skottova & P. Anzenbacher, 2011. "The effect of silymarin on expression of selected ABC transporters in the rat," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 56(2), pages 59-62.

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