IDEAS home Printed from https://ideas.repec.org/a/bpj/sagmbi/v6y2007i1n27.html
   My bibliography  Save this article

On the Operational Characteristics of the Benjamini and Hochberg False Discovery Rate Procedure

Author

Listed:
  • Green Gerwyn H

    (Department of Medicine, Lancaster University)

  • Diggle Peter J.

    (Department of Medicine, Lancaster University & Johns Hopkins Bloomberg School of Public Health)

Abstract

Multiple testing procedures are commonly used in gene expression studies for the detection of differential expression, where typically thousands of genes are measured over at least two experimental conditions. Given the need for powerful testing procedures, and the attendant danger of false positives in multiple testing, the False Discovery Rate (FDR) controlling procedure of Benjamini and Hochberg (1995) has become a popular tool. When simultaneously testing hypotheses, suppose that R rejections are made, of which Fp are false positives. The Benjamini and Hochberg procedure ensures that the expectation of Fp/R is bounded above by some pre-specified proportion. In practice, the procedure is applied to a single experiment. In this paper we investigate the across-experiment variability of the proportion Fp/R as a function of three experimental parameters. The operational characteristics of the procedure when applied to dependent hypotheses are also considered.

Suggested Citation

  • Green Gerwyn H & Diggle Peter J., 2007. "On the Operational Characteristics of the Benjamini and Hochberg False Discovery Rate Procedure," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 6(1), pages 1-23, October.
    • Handle: RePEc:bpj:sagmbi:v:6:y:2007:i:1:n:27
    DOI: 10.2202/1544-6115.1302
    as

    Download full text from publisher

    File URL: https://doi.org/10.2202/1544-6115.1302
    Download Restriction: For access to full text, subscription to the journal or payment for the individual article is required.
    File URL: https://libkey.io/10.2202/1544-6115.1302?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bpj:sagmbi:v:6:y:2007:i:1:n:27. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Peter Golla (email available below). General contact details of provider: https://www.degruyter.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.