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CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data

Author

Listed:
  • Flanagan Keegan

    (Department of Mathematics and Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada)

  • Pelech Steven

    (Department of Medicine, Kinexus Bioinformatics Corporation and University of British Columbia, Vancouver, Canada)

  • Av-Gay Yossef

    (Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada)

  • Dao Duc Khanh

    (Department of Mathematics, University of British Columbia, Vancouver, Canada)

Abstract

Antibody microarray data provides a powerful and high-throughput tool to monitor global changes in cellular response to perturbation or genetic manipulation. However, while collecting such data has become increasingly accessible, a lack of specific computational tools has made their analysis limited. Here we present CAT PETR, a user friendly web application for the differential analysis of expression and phosphorylation data collected via antibody microarrays. Our application addresses the limitations of other GUI based tools by providing various data input options and visualizations. To illustrate its capabilities on real data, we show that CAT PETR both replicates previous findings, and reveals additional insights, using its advanced visualization and statistical options.

Suggested Citation

  • Flanagan Keegan & Pelech Steven & Av-Gay Yossef & Dao Duc Khanh, 2023. "CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 22(1), pages 1-5, January.
    • Handle: RePEc:bpj:sagmbi:v:22:y:2023:i:1:p:5:n:1
    DOI: 10.1515/sagmb-2023-0017
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