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The Benjamini-Hochberg Method in the Case of Discrete Test Statistics

Author

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  • Ferreira José A.

    (Vrije University Medical Centre, Amsterdam)

Abstract

We present a reformulation of the Benjamini-Hochberg method that is useful in 'large-scale' multiple testing problems based on discrete test statistics and derive its basic asymptotic (as the number of hypotheses tends to infinity) properties, subsuming earlier results. A set of gene expression data is used to illustrate the workings of the method in a multiple testing problem based on Kolmogorov-Smirnov and Mann-Whitney statistics.

Suggested Citation

  • Ferreira José A., 2007. "The Benjamini-Hochberg Method in the Case of Discrete Test Statistics," The International Journal of Biostatistics, De Gruyter, vol. 3(1), pages 1-18, July.
    • Handle: RePEc:bpj:ijbist:v:3:y:2007:i:1:n:11
    DOI: 10.2202/1557-4679.1065
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    Cited by:

    1. Stelios Pavlidis & Calixte Monast & Matthew J Loza & Patrick Branigan & Kiang F Chung & Ian M Adcock & Yike Guo & Anthony Rowe & Frédéric Baribaud, 2019. "I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment," PLOS Computational Biology, Public Library of Science, vol. 15(4), pages 1-23, April.
    2. Hui Peng & He Wang & Weijia Kong & Jinyan Li & Wilson Wen Bin Goh, 2024. "Optimizing differential expression analysis for proteomics data via high-performing rules and ensemble inference," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Xiangwei Li & Thomas Delerue & Ben Schöttker & Bernd Holleczek & Eva Grill & Annette Peters & Melanie Waldenberger & Barbara Thorand & Hermann Brenner, 2022. "Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Jihee Kim & Gina Ryu & Jeongmin Seo & Miyeon Go & Gyungmin Kim & Sol Yi & Suwon Kim & Hana Lee & June-Yong Lee & Han Sung Kim & Min-Chan Park & Dong Hae Shin & Hyunbo Shim & Wankyu Kim & Soo Young Lee, 2024. "5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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