IDEAS home Printed from https://ideas.repec.org/a/bla/jorssc/v53y2004i3p507-521.html
   My bibliography  Save this article

Modelling growth and decline in lung function in Duchenne's muscular dystrophy with an augmented linear mixed effects model

Author

Listed:
  • Marc A. Scott
  • Robert G. Norman
  • Kenneth I. Berger

Abstract

Summary. Longitudinal modelling of lung function in Duchenne's muscular dystrophy is complicated by a mixture of both growth and decline in lung function within each subject, an unknown point of separation between these phases and significant heterogeneity between individual trajectories. Linear mixed effects models can be used, assuming a single changepoint for all cases; however, this assumption may be incorrect. The paper describes an extension of linear mixed effects modelling in which random changepoints are integrated into the model as parameters and estimated by using a stochastic EM algorithm. We find that use of this ‘mixture modelling’ approach improves the fit significantly.

Suggested Citation

  • Marc A. Scott & Robert G. Norman & Kenneth I. Berger, 2004. "Modelling growth and decline in lung function in Duchenne's muscular dystrophy with an augmented linear mixed effects model," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 53(3), pages 507-521, August.
  • Handle: RePEc:bla:jorssc:v:53:y:2004:i:3:p:507-521
    DOI: 10.1111/j.1467-9876.2004.05278.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1467-9876.2004.05278.x
    Download Restriction: no

    File URL: https://libkey.io/10.1111/j.1467-9876.2004.05278.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hsin-Fan Chen & Sheng-Hung Chen & Jie-Min Lee, 2024. "Does Risk Perception Endogenously Cause Smokers to Switch to Smoking Smuggled Cigarettes?," Studies in Microeconomics, , vol. 12(3), pages 296-307, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:jorssc:v:53:y:2004:i:3:p:507-521. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://edirc.repec.org/data/rssssea.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.