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Comparison of Two Smoothing Methods for Exploring Waning Vaccine Effects

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  • L. Kathryn Durham
  • M. Elizabeth Halloran
  • Ira M. Longini
  • Amita K. Manatunga

Abstract

We consider the statistical evaluation and estimation of vaccine efficacy when the protective effect wanes with time. We reanalyse data from a 5‐year trial of two oral cholera vaccines in Matlab, Bangladesh. In this field trial, one vaccine appears to confer better initial protection than the other, but neither appears to offer protection for a period longer than about 3 years. Time‐dependent vaccine effects are estimated by obtaining smooth estimates of a time‐varying relative risk RR(t) using survival analysis. We compare two approaches based on the Cox model in terms of their strategies for detecting time‐varying vaccine effects, and their estimation techniques for obtaining a time‐dependent RR(t) estimate. These methods allow an exploration of time‐varying vaccine effects while making minimal parametric assumptions about the functional form of RR(t) for vaccinated compared wit unvaccinated subjects.

Suggested Citation

  • L. Kathryn Durham & M. Elizabeth Halloran & Ira M. Longini & Amita K. Manatunga, 1999. "Comparison of Two Smoothing Methods for Exploring Waning Vaccine Effects," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 48(3), pages 395-407.
    • Handle: RePEc:bla:jorssc:v:48:y:1999:i:3:p:395-407
    DOI: 10.1111/1467-9876.00160
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