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Analysis of Dose–Response Data in the Presence of Extrabinomial Variation

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  • Dennis D. Boos

Abstract

Binary dose–response data often exhibit extrabinomial variation when the responses arise naturally in groups or litters. This paper investigates the use of generalized Wald and score statistics for robustifying the standard inference methods based on the binomial likelihood. Special attention is given to the probit analysis of a parallel assay of the teratogenic effects on mice of several dioxins.

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  • Dennis D. Boos, 1993. "Analysis of Dose–Response Data in the Presence of Extrabinomial Variation," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 42(1), pages 173-183, March.
    • Handle: RePEc:bla:jorssc:v:42:y:1993:i:1:p:173-183
    DOI: 10.2307/2347419
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    Cited by:

    1. Terra L. Slaton & Walter W. Piegorsch & Stephen D. Durham, 2000. "Estimation and Testing with Overdispersed Proportions Using the Beta-Logistic Regression Model of Heckman and Willis," Biometrics, The International Biometric Society, vol. 56(1), pages 125-133, March.

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