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Sparse estimation of Cox proportional hazards models via approximated information criteria

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  • Xiaogang Su
  • Chalani S. Wijayasinghe
  • Juanjuan Fan
  • Ying Zhang

Abstract

type="main" xml:lang="en"> We propose a new sparse estimation method for Cox (1972) proportional hazards models by optimizing an approximated information criterion. The main idea involves approximation of the ℓ 0 norm with a continuous or smooth unit dent function. The proposed method bridges the best subset selection and regularization by borrowing strength from both. It mimics the best subset selection using a penalized likelihood approach yet with no need of a tuning parameter. We further reformulate the problem with a reparameterization step so that it reduces to one unconstrained nonconvex yet smooth programming problem, which can be solved efficiently as in computing the maximum partial likelihood estimator (MPLE). Furthermore, the reparameterization tactic yields an additional advantage in terms of circumventing postselection inference. The oracle property of the proposed method is established. Both simulated experiments and empirical examples are provided for assessment and illustration.

Suggested Citation

  • Xiaogang Su & Chalani S. Wijayasinghe & Juanjuan Fan & Ying Zhang, 2016. "Sparse estimation of Cox proportional hazards models via approximated information criteria," Biometrics, The International Biometric Society, vol. 72(3), pages 751-759, September.
  • Handle: RePEc:bla:biomet:v:72:y:2016:i:3:p:751-759
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    Cited by:

    1. Liuquan Sun & Shuwei Li & Lianming Wang & Xinyuan Song & Xuemei Sui, 2022. "Simultaneous variable selection in regression analysis of multivariate interval‐censored data," Biometrics, The International Biometric Society, vol. 78(4), pages 1402-1413, December.
    2. Dongxiao Han & Xiaogang Su & Liuquan Sun & Zhou Zhang & Lei Liu, 2020. "Variable selection in joint frailty models of recurrent and terminal events," Biometrics, The International Biometric Society, vol. 76(4), pages 1330-1339, December.

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