IDEAS home Printed from https://ideas.repec.org/a/bla/biomet/v64y2008i3p886-894.html
   My bibliography  Save this article

Bayesian Optimal Design for Phase II Screening Trials

Author

Listed:
  • Meichun Ding
  • Gary L. Rosner
  • Peter Müller

Abstract

Summary Most phase II screening designs available in the literature consider one treatment at a time. Each study is considered in isolation. We propose a more systematic decision‐making approach to the phase II screening process. The sequential design allows for more efficiency and greater learning about treatments. The approach incorporates a Bayesian hierarchical model that allows combining information across several related studies in a formal way and improves estimation in small data sets by borrowing strength from other treatments. The design incorporates a utility function that includes sampling costs and possible future payoff. Computer simulations show that this method has high probability of discarding treatments with low success rates and moving treatments with high success rates to phase III trial.

Suggested Citation

  • Meichun Ding & Gary L. Rosner & Peter Müller, 2008. "Bayesian Optimal Design for Phase II Screening Trials," Biometrics, The International Biometric Society, vol. 64(3), pages 886-894, September.
    • Handle: RePEc:bla:biomet:v:64:y:2008:i:3:p:886-894
    DOI: 10.1111/j.1541-0420.2007.00951.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1541-0420.2007.00951.x
    Download Restriction: no
    File URL: https://libkey.io/10.1111/j.1541-0420.2007.00951.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Denis Heng‐Yan Leung & You‐Gan Wang, 2001. "Optimal Designs for Evaluating a Series of Treatments," Biometrics, The International Biometric Society, vol. 57(1), pages 168-171, March.
    2. Nigel Stallard & Peter F. Thall & John Whitehead, 1999. "Decision Theoretic Designs for Phase II Clinical Trials with Multiple Outcomes," Biometrics, The International Biometric Society, vol. 55(3), pages 971-977, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Steffen Ventz & Lorenzo Trippa, 2015. "Bayesian designs and the control of frequentist characteristics: A practical solution," Biometrics, The International Biometric Society, vol. 71(1), pages 218-226, March.
    2. Daniel R. Cavagnaro & Richard Gonzalez & Jay I. Myung & Mark A. Pitt, 2013. "Optimal Decision Stimuli for Risky Choice Experiments: An Adaptive Approach," Management Science, INFORMS, vol. 59(2), pages 358-375, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lurdes Y. T. Inoue & Peter F. Thall & Donald A. Berry, 2002. "Seamlessly Expanding a Randomized Phase II Trial to Phase III," Biometrics, The International Biometric Society, vol. 58(4), pages 823-831, December.
    2. Sambucini, Valeria, 2019. "Bayesian predictive monitoring with bivariate binary outcomes in phase II clinical trials," Computational Statistics & Data Analysis, Elsevier, vol. 132(C), pages 18-30.
    3. Nigel Stallard, 2003. "Decision-Theoretic Designs for Phase II Clinical Trials Allowing for Competing Studies," Biometrics, The International Biometric Society, vol. 59(2), pages 402-409, June.
    4. Steffen Ventz & Lorenzo Trippa, 2015. "Bayesian designs and the control of frequentist characteristics: A practical solution," Biometrics, The International Biometric Society, vol. 71(1), pages 218-226, March.
    5. Peter F. Thall & Hoang Q. Nguyen & Sarah Zohar & Pierre Maton, 2014. "Optimizing Sedative Dose in Preterm Infants Undergoing Treatment for Respiratory Distress Syndrome," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(507), pages 931-943, September.
    6. Nigel Stallard & Peter F. Thall, 2001. "Decision-Theoretic Designs for Pre-Phase II Screening Trials in Oncology," Biometrics, The International Biometric Society, vol. 57(4), pages 1089-1095, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bla:biomet:v:64:y:2008:i:3:p:886-894. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: http://www.blackwellpublishing.com/journal.asp?ref=0006-341X .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.