The Relationship Between D-Dimer Levels and the Value of Prothrombin Time and Activated Partial Thromboplastin Time in Patients with COVID-19 At Rsup Dr. M. Djamil Padang

Covid-19 spread widely resulting in a global pandemic that continues to this day. People who are confirmed to have severe COVID-19 will cause thrombosis which results in increased levels of D-dimer prolonging Prothrombin Time or Activated Partial Thromboplastin Time, increased fibrinogen, and thrombocytopenia. one of the parameters that determine the presence of coagulation can be seen from the levels of D-dimer, PT and APTT. The purpose of this study was to determine the relationship between D-dimer levels and the value of prothrombin time and activated partial thromboplastin time in Covid-19 patients. This research is analytic observational with a cross sectional study design. The sample in this study amounted to 30 respondents. The examination carried out was D-dimer levels using the ELFA (Enzyme Linked Fluorescent Assay) method using Vidas, Prothrombin Time and Activated Partial Thromboplastin Time using the Flouroscence Flowcytometry method using the Sysmex Cs 2500 tool. The data were analyzed using the Spearman’s rho correlation test. The results of the study on Covid-19 average levels of D-dimer 1696.23 g/ml ±1567.448 SD, the value of Prothrombin Time 11.103±1.1898 seconds and Activated Partial Thromboplastin Time 32.643±17.3796 seconds. Conclusion There is a significant relationship between D-dimer levels with the Prothrombin Time P value of 0.003 and with Prothrombin Time and Activated Partial Tromboplastin Time P value of 0.031. There was no significant relationship between D-dimer levels and Activated Partial Tromboplastin Time P value 0.110. High D-dimer levels are accompanied by a prolonged prothrombin time.