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Comparative Analysis of Anti-Proliferative Effect of Zingiber Officinale (Ginger) and Solanum Lycopersicum (Tomatoes) on Testosterone-Induced Benign Prostatic Hyperplasia in Male Albino Rats

Author

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  • Chukwu-Eze U.S.

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

  • Mairiga J.P.

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

  • Ijeomah A.U.

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

  • Enemali, M.O.

    (Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Nigeria)

  • Ukeagbu, M.C.

    (Department of Biology, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Ebonyi State, Nigeria)

  • Maiva E.P.

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

  • Kasar, S.

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

  • Iwuozor, C.R

    (Biochemistry and Molecular Biology Department, Faculty of Natural and Applied Sciences, Nasarawa State University, Nigeria)

Abstract

Benign Prostatic Hyperplasia (BPH) is a debilitating condition that enlarges the prostate and surrounding tissues mostly in men in their 50’s. This inflammatory process can lead to uncontrolled passage of urine, incomplete urine flow, dribbling at the end of urine stream, hematuria and inability to ejaculate. Zingiber officinale (Zo) and Solanum lycopersicum (Sl) are known to have anti-proliferative, anti-oxidant, and anti-inflammatory effect on the prostate. A completely randomized experimental design was used for this study. A comparative analysis of the two plant extracts were carried out against the standard drug dutasteride (Brand name: Tamsudart) on male albino rats for 30 days. The animals were grouped into six. Analysis of Prostate Specific Antigen, C-reactive protein, Serum electrolytes, and stress markers such as malondialdehyde were assayed, and the prostate weight checked. The positive control group were slightly elevated p

Suggested Citation

  • Chukwu-Eze U.S. & Mairiga J.P. & Ijeomah A.U. & Enemali, M.O. & Ukeagbu, M.C. & Maiva E.P. & Kasar, S. & Iwuozor, C.R, 2022. "Comparative Analysis of Anti-Proliferative Effect of Zingiber Officinale (Ginger) and Solanum Lycopersicum (Tomatoes) on Testosterone-Induced Benign Prostatic Hyperplasia in Male Albino Rats," International Journal of Research and Innovation in Applied Science, International Journal of Research and Innovation in Applied Science (IJRIAS), vol. 7(8), pages 64-70, August.
    • Handle: RePEc:bjf:journl:v:7:y:2022:i:8:p:64-70
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