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Effect of Levetiracetam on Juvenile Myoclonic Epilepsy Related Quality of Life

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  • Asha Thomas

    (Department of Pharmacy Practice, Westfort College of Pharmacy)

  • Reshma VB

    (Department of Pharmaceutics, Westfort College of Pharmacy)

  • Hema S

    (Department of Pharmaceutics, Westfort College of Pharmacy)

Abstract

Juvenile myoclonic epilepsy constitutes 5-10% of idiopathic generalized epileptic syndromes. This study was aimed at the efficacy and tolerability of levetiracetam and its effect on the quality of life of juvenile myoclonic epilepsy. This study includes a total of 17 patients with juvenile myoclonic epilepsy who were under levetiracetam treatment. Levetiracetam showed a significant reduction in seizure frequency at the review (after three months) from baseline (p=0.002). And the tolerability was assessed from the occurrence of adverse drug reactions. Headache, somnolence, dizziness, weight gain were found to be the most common side effects of levetiracetam therapy. Since the quality of life is an important treatment outcome indicator in epilepsy, the disease-specific quality of life was measured using the QOLIE-31 (18 years or older) and QOLIE-AD-48 (11 to 17 years old). The study results also showed a greater benefit with the introduction of levetiracetam as there were marked improvements in each dimension of the quality of life and also the total score.

Suggested Citation

  • Asha Thomas & Reshma VB & Hema S, 2021. "Effect of Levetiracetam on Juvenile Myoclonic Epilepsy Related Quality of Life," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 8(2), pages 93-97, February.
    • Handle: RePEc:bjc:journl:v:8:y:2021:i:2:p:93-97
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