Author
Listed:
- Jeremiah Onubi
(Department of Chemical Pathology, College of Medicine and Allied Health Sciences, Bingham University, Karu via Abuja and Jos, Plateau State, Nigeria)
- Oluwagbenga A. Adeola
(Department of Medical Microbiology and Parasitology, College of Medicine and Allied Health Sciences, Bingham University, Karu via Abuja and Jos, Plateau State, Nigeria)
- Patricia Eseigbe
(Department of Family Medicine, College of Medicine and Allied Health Sciences, Bingham University, Karu via Abuja and Jos, Plateau State, Nigeria)
- Adesegun Elisha
(Department of Medical Microbiology and Parasitology, College of Medicine and Allied Health Sciences, Bingham University, Karu via Abuja and Jos, Plateau State, Nigeria)
- Christian Chima Harrison
(APINPublic Health Initiatives, Jos, Plateau State Nigeria)
- Chizoba G. Nwankwo
(Department of Haematology, Nile University of Nigeria, Abuja, Nigeria)
- Anyuku A.G. Chima
(Department of Family Medicine, College of Medicine and Allied Health Sciences, Bingham University, Karu via Abuja and Jos, Plateau State, Nigeria)
Abstract
Achieving viral suppression is crucial for the effective management of HIV. We investigated the prevalence and predictors of unsuppressed viremia among adults living with HIV (PLHIV) on antiretroviral therapy (ART) in the urban city of Jos, Plateau State, North-central Nigeria. A cross-sectional study was conducted with 2,748 PLHIV, comprising 1,902 females (69.2%) and 846 males (30.8%). The majority (71.0%) were aged 36-55 years. Most participants (88.1%) were on the first-line ART regimen tenofovir disoproxil fumarate-lamivudine-dolutegravir (TDF+3TC+DTG), with 6.0% on second-line regimens. The prevalence of unsuppressed viremia (viral load >1,000 copies/mL) was assessed, and predictors were identified using chi-square tests and logistic regression analyses. Overall prevalence of unsuppressed viremia was 4.0% (110 participants), with higher proportions among males (5.6%) compared to females (3.3%) and among those aged 18-35 years (7.9%) compared to other age groups. PLHIV on first-line TDF+3TC+DTG ART had the lowest level of unsuppressed viremia (2.6%). Chi-square tests revealed significant associations between unsuppressed viremia and gender (χ2=7.67, p=0.01), age group (χ2=13.19, p=0.01), and ART regimen (χ2=110.97, p=0.0001). Multivariate logistic regression identified males (AOR=1.69; 95% CI: 1.12-2.56), younger age groups (18-35 years: AOR=12.96; 95% CI: 2.12-79.09 and 36-45 years: AOR=12.84; 95% CI: 3.70-44.64), and non-TDF+3TC+DTG regimens as significant predictors of unsuppressed viremia. The study highlights the effectiveness of the TDF+3TC+DTG regimen and the need for targeted interventions to address disparities in viral suppression, particularly among males and younger individuals. These findings are crucial for optimizing HIV treatment strategies and improving health outcomes for PLHIV in urban areas of low-and-middle-income countries.
Suggested Citation
Jeremiah Onubi & Oluwagbenga A. Adeola & Patricia Eseigbe & Adesegun Elisha & Christian Chima Harrison & Chizoba G. Nwankwo & Anyuku A.G. Chima, 2024.
"Levels and Predictors of Unsuppressed Viremia among People Living with HIV on ART in an Urban Population of North-Central Nigeria: A Retrospective Cross-sectional Study,"
International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 11(8), pages 27-38, August.
Handle:
RePEc:bjc:journl:v:11:y:2024:i:8:p:27-38
Download full text from publisher
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bjc:journl:v:11:y:2024:i:8:p:27-38. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Dr. Renu Malsaria (email available below). General contact details of provider: https://rsisinternational.org/journals/ijrsi/ .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.