Nanoparticle Betacarotene Formulated in Cetyl Alcohol, Glycerine, Stearic Acid and TEA as Based Cream

The effectiveness cream nanobetacorotene (nanosuspension) had been evaluated. This research aims to ensure which one between nanobetacarotene that was better to be produced as a cream after 28 -day observation. The manufacture of nanoparticles is carried out by the ionic gelation low energy method. The characteristics of the nanoparticles tested include particle size and distribution, zeta potential, nanoparticle morphology, encapsulation efficiency The prepared concentrations betacarotene were 0.1%, 0.3%, and 0.5% with in based cream. Cream tested included pH, homogeneity, spreadly, and testing of irritation during 28 days observation: Nanoparticle preparation produces nano suspension in the form of a clear, some -sticky, and odorless solution. The morphology of particle nanoparticles is in the form of square, rectangular and some around shapes, the average value of particle size 187.5 nm; PI 0,288; potential zeta 10 mV; and encapsulation efficiency was 90%. Findings indicate that 0.5 % of nanobetacarotene were more favorable effective formulated cream. None irritating to arm respondent up to 28 days observation.