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Lipid Peroxidation And Expression Of Paraoxonase-1 (Pon-1) Gene In Patients With Preeclampsia

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  • B. O. Arobasalu
  • I. Akinlua

Abstract

Purpose: To evaluate lipid peroxidation and expression of paraoxonase-1 (pon-1) gene in patients with preeclampsia. Methodology: The study comprised of 160 participants, in which 80 were normotensive pregnant women (Group A) and 80 were preeclamptic pregnant women (Group B). Serum MDA levels and PON-1 gene activity were estimated. The expression of data was subjected to statistical analysis using SPSS version 20.0. One-way analysis of variance (ANOVA) was used to compare the test samples, p value <0.05 was considered significant. Findings: MDA levels were significantly elevated in preeclamptic pregnant women when compared to normotensive. Also, PON-1 gene expression levels were significantly decreased in preeclamptic pregnant women when compared to normotensive. Unique contribution to theory, practice and policy: The significant increase in the plasma level of Malondialdehyde and decreases expression of PON-1 gene could be responsible for the presence of oxidative stress and its associated complications in PE patients.

Suggested Citation

  • B. O. Arobasalu & I. Akinlua, 2022. "Lipid Peroxidation And Expression Of Paraoxonase-1 (Pon-1) Gene In Patients With Preeclampsia," International Journal of Health Sciences, CARI Journals Limited, vol. 5(1), pages 8-16.
    • Handle: RePEc:bhx:ojijhs:v:5:y:2022:i:1:p:8-16:id:830
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    File URL: https://carijournals.org/journals/index.php/IJHS/article/view/830/1046
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