IDEAS home Printed from https://ideas.repec.org/a/bfy/ojejhs/v8y2024i5p52-92id2433.html
   My bibliography  Save this article

A Comprehensive Review and Evaluation of Duchenne Muscular Dystrophy (DMD) in a Specific Medical Center: Neurological and Cardiac Implications with a Focus on Retrospective Analysis of 16 Cases

Author

Listed:
  • Amal AlQassmi
  • Huda Khaleel

Abstract

Purpose: The study aimed to investigate the effectiveness of various diagnostic and treatment strategies for Duchenne Muscular Dystrophy (DMD) in a cohort of 16 patients, focusing on their long-term outcomes. Material and Methods: A retrospective analysis was conducted using SPSS tools, including descriptive statistics, correlation analysis, and regression analysis. The study explored the relationship between initial diagnostic findings (CK levels, genetic mutations, ECHO, ECG) and patient outcomes, such as mobility and cardiac health. Findings: The study's findings revealed significant outcomes in the management of Duchenne Muscular Dystrophy (DMD). Notably, 85% of patients treated with corticosteroids experienced a 60% improvement in mobility, while 50% of those receiving physiotherapy were able to maintain ambulation. Regarding cardiac health, the mean age of onset for cardiomyopathy was 12.5 years, with a prevalence rate of 25%, which is lower than in previous studies, suggesting that earlier and more effective interventions were implemented in this cohort. Additionally, the study found that higher CK levels and specific genetic mutations were predictive of more severe disease progression. A comparative analysis with prior research indicated lower rates of wheelchair dependency and cardiomyopathy in this cohort, potentially due to differences in patient demographics and treatment protocols. Implications to Theory, Practice and Policy: This study supports the use of a multidisciplinary approach in DMD management, incorporating early diagnosis, personalized treatment plans, and innovative therapies such as plasmapheresis and gene therapy. It contributes new insights into optimizing care strategies for DMD and underscores the need for further research to validate these findings and explore new treatment avenues.

Suggested Citation

  • Amal AlQassmi & Huda Khaleel, 2024. "A Comprehensive Review and Evaluation of Duchenne Muscular Dystrophy (DMD) in a Specific Medical Center: Neurological and Cardiac Implications with a Focus on Retrospective Analysis of 16 Cases," European Journal of Health Sciences, AJPO Journals Limited, vol. 8(5), pages 52-92.
  • Handle: RePEc:bfy:ojejhs:v:8:y:2024:i:5:p:52-92:id:2433
    as

    Download full text from publisher

    File URL: https://ajpojournals.org/journals/index.php/EJHS/article/view/2433/3216
    Download Restriction: no
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bfy:ojejhs:v:8:y:2024:i:5:p:52-92:id:2433. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chief Editor (email available below). General contact details of provider: https://ajpojournals.org/journals/index.php/EJHS/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.