Hepatic and Glucose Biotolerance Induced by the Aqueous Extract of Leaf of Parkia biglobosa in Rabbit

The aqueous extract of leaves of Parkia biglobosa (Pb) is used in Africa to cure hypertension or for the treatment of immunocompromised individuals. To avoid intoxication of consumers, our study was carried out to evaluate the action of the extract on the level of glucose and liver enzymes [Akaline phosphatase (ALP), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT)]. Two sets of five (5) batches of six (6) rabbits were constituted. The first set each received a single dose of Pb (25, 50, 75 and 100mg/kg body weight or BW) and 0.9% NaCl. The second set were given Methylprednisolone 15mg/kg BW (MP15) and mixtures MP15 and Pb (25, 50, 75 and 100 mg/kg of BW). Rabbit whole blood were collected in dry tubes from the marginal ear vein on the first day before injection (Do), then the 3rd, 9th, 15th and 21th days, was centrifuged. The serum obtained was used for assay of glucose, transaminases and ALP on automate Cobas Integra 400 Plus®. The doses of Pb 25, 50, 75mg/kg of BW did not induce significant changes in transaminases (ALT and AST), ALP and glucose compared to control group (0.9% NaCl) from D0 to D21. However, the dose of 100 mg/kg produced significant increase in transaminases and glucose (p<0.05) levels. The doses of aqueous leaf extract of Parkia biglobosaused were tolerated by the liver and did not involve an hyperglycaemia.