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Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan

Author

Listed:
  • Chen, K.-T.
  • Twu, S.-J.
  • Chang, H.-J.
  • Lin, R.-S.

Abstract

Objectives. This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. Methods. Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. Results. The odds ratio for development of SJS/TEN was 9.5 (95% confidence interval [Cl]=3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. Conclusions. This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.

Suggested Citation

  • Chen, K.-T. & Twu, S.-J. & Chang, H.-J. & Lin, R.-S., 2003. "Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan," American Journal of Public Health, American Public Health Association, vol. 93(3), pages 489-492.
    • Handle: RePEc:aph:ajpbhl:2003:93:3:489-492_3
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