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A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area

Author

Listed:
  • Desvarieux, M.
  • Hyppolite, P.-R.
  • Johnson W.D., Jr.
  • Pape, J.W.

Abstract

Objectives. This study evaluated a novel approach to the delivery of directly observed therapy (DOT) for tuberculosis in Haiti. Methods. A total of 194 patients (152 HIV seropositive, 42 HIV seronegative) received daily unsupervised triple-drug therapy for 4 to 8 weeks, followed by twice-weekly 2-drug therapy for the remainder of the 6-month period. DOT was deferred until initiation of the twice-weekly phase. Results. A total of 169 of 194 patients (87.1%) completed the 6-month course. The program of deferred DOT had an effectiveness of 85%. Overall cost was reduced by approximately 40%. Conclusions. Flexible approaches to DOT, integrating behavioral knowledge, cost considerations, and practicality may improve completion rates and program effectiveness.

Suggested Citation

  • Desvarieux, M. & Hyppolite, P.-R. & Johnson W.D., Jr. & Pape, J.W., 2001. "A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area," American Journal of Public Health, American Public Health Association, vol. 91(1), pages 138-141.
    • Handle: RePEc:aph:ajpbhl:2001:91:1:138-141_1
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