IDEAS home Printed from https://ideas.repec.org/a/aph/ajpbhl/1999895731-736_3.html
   My bibliography  Save this article

Minor tobacco alkaloids as biomarkers for tobacco use: Comparison of users of cigarettes, smokeless tobacco, cigars, and pipes

Author

Listed:
  • Jacob III, P.
  • Yu, L.
  • Shulgin, A.T.
  • Benowitz, N.L.

Abstract

Objectives. This study (1) determined levels of various tobacco alkaloids in commercial tobacco products; (2) determined urinary concentrations, urinary excretion, and half-lives of the alkaloids in humans; and (3) examined the possibility that urine concentrations of nicotine- related alkaloids can be used as biomarkers of tobacco use. Methods. Nicotine intake from various tobacco products was determined through pharmacokinetic techniques. Correlations of nicotine intake with urinary excretion and concentrations of anabasine, anatabine, nornicotine, nicotine, and cotinine were examined. By using urinary excretion data, elimination half-lives of the alkaloids were calculated. Results. Alkaloid levels in commercial tobacco products, in milligrams per gram, were as follows: nicotine, 6.5 to 17.5; nornicotine, 0.14 to 0.66; anabasine, 0.008 to 0.030; and anatabine, 0.065 to 0.27. Measurable concentrations of all alkaloids were excreted in the urine of most subjects smoking cigarettes, cigars, and pipes and using smokeless tobacco. Correlations between nicotine intake and alkaloid concentrations were good to excellent. Conclusions. Anabasine and anatabine, which are present in tobacco but not in nicotine medications, can be used to assess tobacco use in persons undergoing nicotine replacement therapy.

Suggested Citation

  • Jacob III, P. & Yu, L. & Shulgin, A.T. & Benowitz, N.L., 1999. "Minor tobacco alkaloids as biomarkers for tobacco use: Comparison of users of cigarettes, smokeless tobacco, cigars, and pipes," American Journal of Public Health, American Public Health Association, vol. 89(5), pages 731-736.
  • Handle: RePEc:aph:ajpbhl:1999:89:5:731-736_3
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yen‐Chung Ho & Hsin‐Chien Lee & Mei‐Feng Lin & Hsiu‐Ju Chang, 2020. "Correlations among life stress, smoking behavior, and depressive symptoms in adolescents: A descriptive study with a mediating model," Nursing & Health Sciences, John Wiley & Sons, vol. 22(4), pages 949-957, December.
    2. Dominic Palazzolo & John M. Nelson & Zuri Hudson, 2019. "The Use of HPLC-PDA in Determining Nicotine and Nicotine-Related Alkaloids from E-Liquids: A Comparison of Five E-Liquid Brands Purchased Locally," IJERPH, MDPI, vol. 16(17), pages 1-13, August.
    3. Sungroul Kim & Benjamin J. Apelberg & Erika Avila-Tang & Lisa Hepp & Dongmin Yun & Jonathan M. Samet & Patrick N. Breysse, 2014. "Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine," IJERPH, MDPI, vol. 11(8), pages 1-15, August.
    4. Tiller, Kelly & Starnes, Jane H. & Feleke, Shiferaw T., 2010. "What Does the “Family Smoking Prevention and Tobacco Control Act” Mean to Tobacco Growers?," 2010 Annual Meeting, February 6-9, 2010, Orlando, Florida 56448, Southern Agricultural Economics Association.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:aph:ajpbhl:1999:89:5:731-736_3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F Baum (email available below). General contact details of provider: https://www.apha.org .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.