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Duration of protective immunity conferred by maternal tetanus toxoid immunization: Further evidence from Matlab, Bangladesh

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  • Koenig, M.A.
  • Roy, N.C.
  • McElrath, T.
  • Shahidullah
  • Wojtyniak, B.

Abstract

Objectives. Although maternal tetanus immunization has been shown to be highly effective in the prevention of neonatal tetanus, unresolved questions remain concerning the required minimum number of doses and the resulting duration of effective immunity. This study examined the duration of effective immunity against neonatal tetanus provided by maternal tetanus immunization. Methods. A randomized, double-blind cholera vaccine trial of 41 571 children and nonpregnant adult women carried out in 1974 in the Matlab comparison area of rural Bangladesh provided a unique opportunity to address dose and immunity issues. Results. Children of women who received either 1 or 2 injections of tetanus toxoid experiences 4- to 14-day mortality levels consistently lower than those of children of unimmunized mothers. Analysis of neonatal-tetanus-related mortality showed that 2 injections of tetanus toxoid provided significant protection for subsequent durations of up to 12 or 13 years. Conclusions. The data demonstrate that a limited-dose regimen of maternal tetanus toxoid provides significant and extended protection against the risk of neonatal tetanus death.

Suggested Citation

  • Koenig, M.A. & Roy, N.C. & McElrath, T. & Shahidullah & Wojtyniak, B., 1998. "Duration of protective immunity conferred by maternal tetanus toxoid immunization: Further evidence from Matlab, Bangladesh," American Journal of Public Health, American Public Health Association, vol. 88(6), pages 903-907.
    • Handle: RePEc:aph:ajpbhl:1998:88:6:903-907_6
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    Cited by:

    1. Yacoubian, George S., 2001. "Assessing the temporal stability of drug-using classifications: An examination of Washington, DC arrestees between 1990 and 1997," Journal of Criminal Justice, Elsevier, vol. 29(1), pages 21-30.
    2. J. Driessen & A. Razzaque & D. Walker & D. Canning, 2015. "The effect of childhood measles vaccination on school enrolment in Matlab, Bangladesh," Applied Economics, Taylor & Francis Journals, vol. 47(55), pages 6019-6040, November.
    3. Canning, David & Razzaque, Abdur & Driessen, Julia & Walker, Damian G. & Streatfield, Peter Kim & Yunus, Mohammad, 2011. "The effect of maternal tetanus immunization on children's schooling attainment in Matlab, Bangladesh: Follow-up of a randomized trial," Social Science & Medicine, Elsevier, vol. 72(9), pages 1429-1436, May.
    4. Sajida Amin, 2008. "Popular Perceptions of Emerging Influences on Mortality and Longevity in Bangladesh and West Bengal," Working Papers id:1454, eSocialSciences.
    5. McGovern, Mark E. & Canning, David, 2015. "Vaccination and All Cause Child Mortality 1985-2011: Global Evidence from the Demographic and Health Surveys," Working Paper 227741, Harvard University OpenScholar.

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