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The Boston AIDS Survival Score (BASS): A multidimensional AIDS severity instrument

Author

Listed:
  • Seage III, G.R.
  • Gatsonis, C.
  • Weissman, J.
  • Haas, J.
  • Cleary, P.
  • Fowler, F.
  • Massagli, M.P.
  • Stone, V.E.
  • Craven, D.E.
  • Makadon, H.
  • Goldberg, J.
  • Coltin, K.
  • Levin, K.S.
  • Epstein, A.M.

Abstract

Objectives. This study developed a new acquired immunodeficiency syndrome (AIDS) severity system by including diagnostic, physiological, functional, and sociodemographic factors predictive of survival. Methods. Three-hundred five persons with AIDS in Boston were interviewed; their medical records were reviewed and vital status ascertained. Results. Overall median (±SD) survival for the cohort from the first interview until death was 560 ± 14.4 days. The best model for predicting survival, the Boston AIDS Survival Score, included the Justice score (stage 2 relative hazard [RH] = 1.25, 95% confidence interval [CI] = 0.80, 1.96; stage 3 RH = 1.76. 95% CI = 1.15, 2.70), a newly developed opportunistic disease score (Boston Opportunistic Disease Survival Score; stage 2 RH = 1.35, 95% CI = 0.90, 2.02; stage 3 RH = 2.10, 95% CI = 1.38, 3.18), and measures of activities of daily living (any intermediate limitations, RH = 1.84, 95% CI = 1.05, 3.21; any basic limitations, RH = 2.60, 95% CI = 1.44, 4.69). This model had substantially greater predictive power (R 2 = .17, C statistic = .68) than the Justice score alone (R 2 = .09, C statistic = .61). Conclusions. Incorporating data on clinically important events and functional status into a physiologically based system can improve the prediction of survival with AIDS.

Suggested Citation

  • Seage III, G.R. & Gatsonis, C. & Weissman, J. & Haas, J. & Cleary, P. & Fowler, F. & Massagli, M.P. & Stone, V.E. & Craven, D.E. & Makadon, H. & Goldberg, J. & Coltin, K. & Levin, K.S. & Epstein, A.M., 1997. "The Boston AIDS Survival Score (BASS): A multidimensional AIDS severity instrument," American Journal of Public Health, American Public Health Association, vol. 87(4), pages 567-573.
    • Handle: RePEc:aph:ajpbhl:1997:87:4:567-573_2
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