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Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women

Author

Listed:
  • Folsom, A.R.
  • Mink, P.J.
  • Sellers, T.A.
  • Hong, C.-P.
  • Zheng, W.
  • Potter, J.D.

Abstract

We assessed the association of hormonal replacement therapy with mortality and incidence of multiple diseases in over 40 000 postmenopausal women followed for 6 years as part of the Iowa Women's Health Study. Compared with women who never used hormone replacement therapy, current users had multivariate adjusted relative risks (RR) as follows: total mortality (RR = 0.78; 95% confidence interval [CI] = 0.65, 0.94), coronary heart disease mortality (RR = 0.74; 95% CI = 0.48, 1.12), endometrial cancer incidence (RR = 4.3; 95% CI = 2.7, 6.9), breast cancer incidence (RR = 1.23; 95% CI = 0.99, 1.55), colon cancer incidence (RR = 0.72; 95% CI = 0.46, 1.12), and hip fracture incidence (RR = 0.53; 95% CI = 0.31, 0.91).

Suggested Citation

  • Folsom, A.R. & Mink, P.J. & Sellers, T.A. & Hong, C.-P. & Zheng, W. & Potter, J.D., 1995. "Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women," American Journal of Public Health, American Public Health Association, vol. 85(8), pages 1128-1132.
    • Handle: RePEc:aph:ajpbhl:1995:85:8:1128-1132_1
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