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The changing epidemiology of invasive bacterial infections in Massachusetts children, 1984 through 1991

Author

Listed:
  • Loughlin, A.M.
  • Marchant, C.D.
  • Lett, S.M.

Abstract

Coincident with the licensure of Haemophilus influenzae b conjugate vaccines from 1987 to 1990, the incidence of meningitis and other invasive infections caused by H influenzae type b declined in Massachusetts children by 87% and 91%, respectively. By 1991, Neisseria meningitidis had replaced H influenzae b as the leading cause of bacterial meningitis, accounting for 57% of cases. During the period 1984 through 1991, serogroup C displaced serogroup B as the most common cause of N meningitidis disease. Streptococcus pneumoniae caused 92% of nonmeningitis invasive disease, with serogroups 14, 6, 19, 18, 4, 2.3, and 9 causing 94.5% of infections. These finding have implications for the development of additional polysaccharide-protein conjugate vaccines for the prevention of childhood infections.

Suggested Citation

  • Loughlin, A.M. & Marchant, C.D. & Lett, S.M., 1995. "The changing epidemiology of invasive bacterial infections in Massachusetts children, 1984 through 1991," American Journal of Public Health, American Public Health Association, vol. 85(3), pages 392-394.
    • Handle: RePEc:aph:ajpbhl:1995:85:3:392-394_0
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