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A decision-analytic approach to postexposure rabies prophylaxis

Author

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  • Cantor, S.B.
  • Clover, R.D.
  • Thompson, R.F.

Abstract

The risks and benefits of postexposure rabies prophylaxis were analyzed from clinical and economic perspectives. A decision-analytic model was constructed by using probability and outcome data from the literature and the state health department. Health outcomes were measured in quality-adjusted life years. In the base case (overweight adult male), treatment is optimal when the probability of animal rabidity is greater than 1 in 2000. Sensitivity analysis showed robustness in the treatment decision; however, the incremental cost-effectiveness ratio ($140 000/quality-adjusted life year) is sensitive to the rabidity probability. Treatment is optimal from the patient's perspective; however, it may not be cost-effective when the probability of rabidity is low.

Suggested Citation

  • Cantor, S.B. & Clover, R.D. & Thompson, R.F., 1994. "A decision-analytic approach to postexposure rabies prophylaxis," American Journal of Public Health, American Public Health Association, vol. 84(7), pages 1144-1148.
    • Handle: RePEc:aph:ajpbhl:1994:84:7:1144-1148_0
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    Cited by:

    1. Harris, Ryan A. & Nease, Robert Jr., 1997. "The importance of patient preferences for comorbidities in cost-effectiveness analyses," Journal of Health Economics, Elsevier, vol. 16(1), pages 113-119, February.

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