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Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

Author

Listed:
  • Vernacchio, L.
  • Madico, G.
  • Verastegui, M.
  • Diaz, F.
  • Collins, T.S.
  • Gilman, R.H.

Abstract

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

Suggested Citation

  • Vernacchio, L. & Madico, G. & Verastegui, M. & Diaz, F. & Collins, T.S. & Gilman, R.H., 1993. "Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test," American Journal of Public Health, American Public Health Association, vol. 83(12), pages 1754-1756.
    • Handle: RePEc:aph:ajpbhl:1993:83:12:1754-1756_0
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