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Factors influencing the formation of new human coronary lesions: Age, blood pressure, and blood cholesterol

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  • Mack, W.J.
  • Blankenhorn, D.H.

Abstract

Background. The Cholesterol Lowering Atherosclerosis Study, a controlled angiographic trial, has reported that new native coronary artery lesions are significantly reduced by aggressive blood lipid lowering therapy with colestipol plus niacin. To study factors relevant to primary atherosclerosis prevention, we have conducted an epidemiologic analysis of new native coronary lesion formation in placebo-treated patients. Methods. Univariate and multivariate logistic regression procedures were used to examine age at entry into the study, number of years since bypass, body weight, diastolic and systolic blood pressure, plasma total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, non-HDL-cholesterol, and apolipoproteins A-I,B, and C-III. Results. Significant univariate protective factors were older age (P

Suggested Citation

  • Mack, W.J. & Blankenhorn, D.H., 1991. "Factors influencing the formation of new human coronary lesions: Age, blood pressure, and blood cholesterol," American Journal of Public Health, American Public Health Association, vol. 81(9), pages 1180-1184.
    • Handle: RePEc:aph:ajpbhl:1991:81:9:1180-1184_9
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