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Spermicide use and Down's syndrome

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  • Rothman, K.J.

Abstract

A connection has been suggested between use of vaginal spermicides and the occurrence of Down's syndrome among offspring born to women who used these contraceptive agents. This hypothesis was evaluated with data from a case-control study of congenital heart disease, which included among the subjects 16 infants with Down's syndrome. The estimated ratio of the proportion of Down's syndrome births among spermicide users to the proportion in non-users was 3.6, with a 90 per cent confidence interval of 1.2 to 9.0, thus providing a tentative confirmation of the hypothesis.

Suggested Citation

  • Rothman, K.J., 1982. "Spermicide use and Down's syndrome," American Journal of Public Health, American Public Health Association, vol. 72(4), pages 399-401.
    • Handle: RePEc:aph:ajpbhl:1982:72:4:399-401_4
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    Cited by:

    1. Jeffrey E. Harris, 2020. "Geospatial Analysis of the September 2020 Coronavirus Outbreak at the University of Wisconsin – Madison: Did a Cluster of Local Bars Play a Critical Role?," NBER Working Papers 28132, National Bureau of Economic Research, Inc.

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