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Social regulation of human gene expression: Mechanisms and implications for public health

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  • Cole, S.W.

Abstract

Recent analyses have discovered broad alterations in the expression of human genes across different social environments. The emerging field of social genomics has begun to identify the types of genes sensitive to social regulation, the biological signaling pathways mediating these effects, and the genetic polymorphisms that modify their individual impact. The human genome appears to have evolved specific "social programs" to adapt molecular physiology to the changing patterns of threat and opportunity ancestrally associated with changing social conditions. In the context of the immune system, this programming now fosters many of the diseases that dominate public health. The embedding of individual genomes within a broader metagenomic network provides a framework for integrating molecular, physiologic, and social perspectives on human health.

Suggested Citation

  • Cole, S.W., 2013. "Social regulation of human gene expression: Mechanisms and implications for public health," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 84-92.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2012.301183_6
    DOI: 10.2105/AJPH.2012.301183
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    Cited by:

    1. Zhiyuan Yu & Steve Cole & Kharah Ross & Martha Hart & Lubna Anis & Nicole Letourneau, 2024. "Childhood Adversities and the ATTACH TM Program’s Influence on Immune Cell Gene Expression," IJERPH, MDPI, vol. 21(6), pages 1-11, June.
    2. Homa Pourriyahi & Niloufar Yazdanpanah & Amene Saghazadeh & Nima Rezaei, 2021. "Loneliness: An Immunometabolic Syndrome," IJERPH, MDPI, vol. 18(22), pages 1-24, November.
    3. Joly, Marcel & Rondó, Patrícia H.C., 2017. "The future of computational biomedicine: Complex systems thinking," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 132(C), pages 1-27.
    4. Karunamuni, Nandini & Imayama, Ikuyo & Goonetilleke, Dharshini, 2021. "Pathways to well-being: Untangling the causal relationships among biopsychosocial variables," Social Science & Medicine, Elsevier, vol. 272(C).
    5. Gabriella M. McLoughlin & Eric M. Wiedenman & Sarah Gehlert & Ross C. Brownson, 2020. "Looking beyond the Lamppost: Population-Level Primary Prevention of Breast Cancer," IJERPH, MDPI, vol. 17(23), pages 1-11, November.
    6. Levine, M.E. & Cole, S.W. & Weir, D.R. & Crimmins, E.M., 2015. "Childhood and later life stressors and increased inflammatory gene expression at older ages," Social Science & Medicine, Elsevier, vol. 130(C), pages 16-22.

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