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The statin-iron nexus: Anti-inflammatory intervention for arterial disease prevention

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  • Zacharski, L.R.
  • DePalma, R.G.
  • Shamayeva, G.
  • Chow, B.K.

Abstract

Objectives: We postulated the existence of a statin-iron nexus by which statins improve cardiovascular disease outcomes at least partially by countering proinflammatory effects of excess iron stores. Methods: Using data from a clinical trial of iron (ferritin) reduction in advanced peripheral arterial disease, the Iron and Atherosclerosis Study, we compared effects of ferritin levels versus high-density lipoprotein to low-density lipoprotein ratios (both were randomization variables) on clinical outcomes in participants receiving and not receiving statins. Results: Statins increased high-density lipoprotein to low-density lipoprotein ratios and reduced ferritin levels by noninteracting mechanisms. Improved clinical outcomes were associated with lower ferritin levels but not with improved lipid status. Conclusions: There are commonalities between the clinical benefits of statins and the maintenance of physiologic iron levels. Iron reduction may be a safe and low-cost alternative to statins.

Suggested Citation

  • Zacharski, L.R. & DePalma, R.G. & Shamayeva, G. & Chow, B.K., 2013. "The statin-iron nexus: Anti-inflammatory intervention for arterial disease prevention," American Journal of Public Health, American Public Health Association, vol. 103(4), pages 105-112.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2012.301163_4
    DOI: 10.2105/AJPH.2012.301163
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