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Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: A randomized controlled trial

Author

Listed:
  • Tsai, A.C.
  • Karasic, D.H.
  • Hammer, G.P.
  • Charlebois, E.D.
  • Ragland, K.
  • Moss, A.R.
  • Sorensen, J.L.
  • Dilley, J.W.
  • Bangsberg, D.R.

Abstract

Objectives. We assessed whether directly observed fluoxetine treatment reduced depression symptom severity and improved HIV outcomes among homeless and marginally housed HIV-positive adults in San Francisco, California, from 2002 to 2008. Methods. We conducted a nonblinded, randomized controlled trial of onceweekly fluoxetine, directly observed for 24 weeks, then self-administered for 12 weeks (n = 137 persons with major or minor depressive disorder or dysthymia). Hamilton Depression Rating Scale score was the primary outcome. Response was a 50% reduction from baseline and remission a score below 8. Secondary measures were Beck Depression Inventory-II (BDI-II) score, antiretroviral uptake, antiretroviral adherence (measured by unannounced pill count), and HIV-1 RNA viral suppression (

Suggested Citation

  • Tsai, A.C. & Karasic, D.H. & Hammer, G.P. & Charlebois, E.D. & Ragland, K. & Moss, A.R. & Sorensen, J.L. & Dilley, J.W. & Bangsberg, D.R., 2013. "Directly observed antidepressant medication treatment and HIV outcomes among homeless and marginally housed HIV-positive adults: A randomized controlled trial," American Journal of Public Health, American Public Health Association, vol. 103(2), pages 308-315.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2011.300422_1
    DOI: 10.2105/AJPH.2011.300422
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    Cited by:

    1. Tsai, Alexander C. & Burns, Bridget F.O., 2015. "Syndemics of psychosocial problems and HIV risk: A systematic review of empirical tests of the disease interaction concept," Social Science & Medicine, Elsevier, vol. 139(C), pages 26-35.
    2. Tsai, Alexander C. & Venkataramani, Atheendar S., 2015. "The causal effect of education on HIV stigma in Uganda: Evidence from a natural experiment," Social Science & Medicine, Elsevier, vol. 142(C), pages 37-46.

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