IDEAS home Printed from https://ideas.repec.org/a/aph/ajpbhl/10.2105-ajph.2008.137901_6.html
   My bibliography  Save this article

Association between HIV-1 RNA level and CD4 cell count among untreated HIV-infected individuals

Author

Listed:
  • Lima, V.D.
  • Fink, V.
  • Yip, B.
  • Hogg, R.S.
  • Harrigan, P.R.
  • Montaner, J.S.

Abstract

OBJECTIVES: We examined the significance of plasma HIV-1 RNA levels (or viral load alone) in predicting CD4 cell decline in untreated HIV-infected individuals. METHODS: Data were obtained from the British Columbia Centre for Excellence in HIV/AIDS. Participants included all residents who ever had a viral load determination in the province and who had never taken antiretroviral drugs (N = 890). We analyzed a total of 2074 viral load measurements and 2332 CD4 cell counts. Linear mixed-effects models were used to predict CD4 cell decline over time. RESULTS: Longitudinal viral load was strongly associated with CD4 cell decline over time; an average of 1 log(10) increase in viral load was associated with a 55-cell/mm(3) decrease in CD4 cell count. CONCLUSIONS: Our results support the combined use of CD4 cell count and viral load as prognostic markers in HIV-infected individuals before the introduction of antiretroviral therapy.

Suggested Citation

  • Lima, V.D. & Fink, V. & Yip, B. & Hogg, R.S. & Harrigan, P.R. & Montaner, J.S., 2009. "Association between HIV-1 RNA level and CD4 cell count among untreated HIV-infected individuals," American Journal of Public Health, American Public Health Association, vol. 99(S1), pages 193-196.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2008.137901_6
    DOI: 10.2105/AJPH.2008.137901
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.2105/AJPH.2008.137901
    Download Restriction: no
    File URL: https://libkey.io/10.2105/AJPH.2008.137901?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Asres Berhan & Yifru Berhan, 2013. "Virologic Response to Tipranavir-Ritonavir or Darunavir-Ritonavir Based Regimens in Antiretroviral Therapy Experienced HIV-1 Patients: A Meta-Analysis and Meta-Regression of Randomized Controlled Clin," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:aph:ajpbhl:10.2105/ajph.2008.137901_6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F Baum (email available below). General contact details of provider: https://www.apha.org .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.