Comparison of platelet rich plasma administration with platelet low plasma for healing incision wounds in cruris of rattus norvegicus rats viewed from histology of collagen tissues

Wound healing is a complicated, multi-step process that can be divided into three major phases: inflammation, proliferation, and scar formation/remodeling. The compartmentalization of this process into discrete stages gives the illusion of simplicity, but in reality it is much more complicated. For efficient healing to occur, complex interac- tions between multiple cell types, soluble factors and extracellular matrix components are required to re-build the tissue, Platelet Rich Plasma (PRP) is produced from the blood by centrifugation, which concentrates platelets along with several bioactive factors that have the ability to promote various aspects of tissue regeneration and protection The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply and release supraphysiologic amounts of essential growth factors and cytokines from their alpha granules to provide a regenerative stimulus that augments healing and promotes repair in tissues. Unlike PRP, Platelet Poor Plasma (PPP) does not have many platelets but PPP has its own unique healing properties.This study was an experimental study using the design of the post- test only control group design in an experimental laboratory. The research subjects were divided into 3 groups: 10 rats with incision wound at the cruris and given injection of PRP, then 10 white rats with incision wound at the cruris and were given injection of platelet-poor plasma and 10 rats with incision wound at the cruris for control. The wound area was measured over 7 days, the wound was harvested and histological analysis was performed including counting of collagen finding, and will be analyzed by ANOVA test. The results showed that the amount of collagen between PRP and PPP differ significantly with p velue 0.000 (p