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Clinical Evaluation of Serum Alpha Feto-Protein (AFP) and Interlukin-6 in Hepatocellular Carcinoma

Author

Listed:
  • S.S. Haque
  • Bandana Kumari
  • M.A. Muzaffar
  • Rekha Kumari
  • U. Kuma
  • A Saran
  • Md. Tanweeruddin
  • Pawan Kumar

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the important cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of interleukin-6 (IL-6) and α-Fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC).Patients and methods: We studied both IL-6 and AFP in patients with HCC or in healthy controls. Serum IL-6, AFP was measured by enzyme linked immunosorbent assay and Chemiluminescent immunoassay respectively in 30 patients with primary hepatocellular carcinoma and 30 normal subjectsResults:IL-6 and AFP was found in high levels in the serum of patients initially diagnosed with HCC (18±9.8), and (315.99±594.62) respectively compared with healthy subjects (4.29±2.10).and (3.13±1.27).A significant positive correlation was found between mean levels of IL- 6 & AFP in HCC (P < 0.05), Combination of IL-6 and AFP improved the sensitivity in diagnosing HCC or predicting future HCC development. Conclusions: IL-6 along with AFP could be considered a promising tumor marker for HCC. In particular, the diagnostic value of the test is significantly increased when combined with AFP.

Suggested Citation

  • S.S. Haque & Bandana Kumari & M.A. Muzaffar & Rekha Kumari & U. Kuma & A Saran & Md. Tanweeruddin & Pawan Kumar, 2014. "Clinical Evaluation of Serum Alpha Feto-Protein (AFP) and Interlukin-6 in Hepatocellular Carcinoma," Journal of Life Sciences Research, Asian Online Journal Publishing Group, vol. 1(1), pages 21-23.
    • Handle: RePEc:aoj:lifscr:v:1:y:2014:i:1:p:21-23:id:591
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    Keywords

    AFP; HCC; IL-6.;
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