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Individualized techniques of Implant Coating with an Antibiotic-loaded, Hydroxyapatite/Calcium sulphate Bone Graft Substitute

Author

Listed:
  • Holger Freischmidt
  • Jonas Armbruster

    (BG Unfallklinik Ludwigshafen, Klinik für Unfallchirurgie und Orthopädie, Ludwig-Guttmann-Strasse 13, 67071 Ludwigshafen, Germany)

  • Gregor Reiter
  • Paul Alfred Grützner

    (Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Germany)

  • Lars Helbig
  • Thorsten Guehring

    (Arcus Kliniken Pforzheim, Germany)

Abstract

The treatment of fracture- or non-union- related infections has persistently been a major challenge for both patients and treating surgeons. With rising aging of patients and increasing comorbidities, combined with the heterogeneity of germs and any number of multi-resistance against standard antibiotics, a successful treatment is increasingly difficult. One potential solution could be a custom-made individualized antibacterial coating of standard implants with a biphasic degradable biocarrier that releases high doses of antibiotics around the bone-implant-interface. Here we describe our technique of coating intramedullary nails, plates and press-fit shoulder endoprostheses which may prevent bacterial adhesion and biofilm formation. So far, there is very limited experience in individual coating of implants in hip or knee endoprostheses to prevent reoccurrence of surgical-site infection. Currently no reports are available for coating of stems of shoulder prosthesis and nails or plates for fracture fixation.

Suggested Citation

  • Holger Freischmidt & Jonas Armbruster & Gregor Reiter & Paul Alfred Grützner & Lars Helbig & Thorsten Guehring, 2019. "Individualized techniques of Implant Coating with an Antibiotic-loaded, Hydroxyapatite/Calcium sulphate Bone Graft Substitute," Orthopedics and Rheumatology Open Access Journals, Juniper Publishers Inc., vol. 15(3), pages 65-70, December.
    • Handle: RePEc:adp:joroaj:v:15:y:2019:i:3:p:65-70
    DOI: 10.19080/OROAJ.2019.15.555912
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