Variability of Clinical and Paraclinical Manifestations in Antiphospholipid Antibody Syndrome - Two Case Reports and Literature Review

Antiphospholipid antibody syndrome is a well- known, although rare, autoimmune condition characterized by thromboembolic events and/ or pregnancy morbidity, in the presence of antiphospholipid antibodies. We present the cases of two women (aged 59 and 37 years old), both diagnosed with this disease, but having different forms of manifestation; the first one consists of recurrent episodes of pulmonary embolies and renal impairment, with relatively late onset, while the second case describes early history of pregnancy morbidity in a young patient that also presents kidney function alterations; both patients have suggestive serology. A kidney biopsy was performed in both cases. The particularity of antiphospholipid syndrome as a pathological entity consists in its clinical variability and heterogenicity, therefore, whenever there are signs of thrombosis or pregnancy complications, this condition must be suspected and further investigated.